Pneumonia remains a leading cause of morbidity and mortality worldwide, particularly in resource-limited settings and among elderly populations...

Macrofungi signify an extensive reservoir of bioactive metabolites. Still, their chemical description is stalled by fragmented analytical pipelines and low reproducibility. This study introduces SysFungiNet, a unified, FAIR-compliant systems-bioinformatics framework designed to accelerate bioactives discovery in non-model fungi. Unlike existing pipelines, SysFungiNet integrates LC-MS/MS metabolomics, transcriptomics, and genomic data with explainable artificial intelligence and molecular docking validation. By reconstructing biosynthetic pathways for Ganoderma lucidum and Craterellus cornucopioides, the framework achieved a Pathway Completeness Index of 0.86. An ensemble machine-learning model predicted bioactivity with an F1-score of 0.91, identifying 312 annotated metabolites. Crucially, decision-making was transparent, with SHAP analysis identifying specific chemical substructures driving predicted immunomodulation. The framework prioritized five high-confidence candidates, including a putative novel terpenoid, Cornucopiolide, which showed high binding affinity (−9.4 kcal/mol) to human immune receptors in silico. Benchmarking against MetaFungi and PhytoOmics demonstrated superior annotation accuracy and reproducibility. SysFungiNet offers a scalable, open-source ecosystem for transforming fungal bioprospecting into an evidence-driven process.

Depression remains one of the most serious mental health challenges worldwide and is often underdiagnosed due to social stigma and limited access to medical services. With the proliferation of social media as a medium for self-expression, these platforms provide new opportunities for early detection of depressive symptoms through digital footprints. However, most prior research has primarily focused on linguistic features derived from text, overlooking behavioral dynamics that also reflect psychological states. To address this gap, we propose Depress-HybridNet, a hybrid deep learning framework that integrates linguistic embeddings with behavioral activity patterns. The architecture combines a BERT-BiLSTM encoder for linguistic feature extraction, a multi-layer perceptron for behavioral feature encoding, and an adaptive attention-based fusion mechanism to integrate multimodal signals optimally. Experiments conducted on the publicly available Kaggle Depression Dataset demonstrate that Depress-HybridNet consistently outperforms strong baselines, including fine-tuned BERT, achieving state-of-the-art results (F1 = 0.92, AUC = 0.93). A further ablation study highlights the critical role of behavioral features and the attention fusion layer in improving performance. In addition, clinical validation by licensed psychologists confirmed a high degree of consistency between the model’s predictions and expert judgment, underscoring its real-world applicability. These findings underscore the importance of modelling depression as a multifaceted phenomenon, rather than a purely linguistic task, and establish a reproducible benchmark for future research.